Sipples syndrome

(J.H Sipple - U.S Physician)
MEN - , designated as type 1 ( Wermers syndrome), type 2A (Sipples syndrome), and type2B.
These involve tumour formation or hyperplasia in various combinations of endocrine glands.
Type 1 involves the parathyroid, pituitary, and pancreas, whereas type 2A involves the thyroid medullary cells, the adrenal medulla (phaeochromocytoma), and the parathyroids.
Type 2B is similar to 2A, but patients tend to resemble people with Marfans syndrome and have multiple neuroma on their mucous membranes.